Abstract
This Letter describes optimization of ghrelin receptor antagonists and inverse agonists starting from a screening hit.
MeSH terms
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Animals
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Anti-Obesity Agents / chemical synthesis
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Anti-Obesity Agents / chemistry*
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Anti-Obesity Agents / pharmacology
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Benzenesulfonamides
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Cell Line
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Drug Design
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Drug Inverse Agonism
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Humans
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Male
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Obesity / drug therapy
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Rats
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Rats, Sprague-Dawley
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Receptors, Ghrelin / antagonists & inhibitors*
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Receptors, Ghrelin / metabolism
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Structure-Activity Relationship
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Sulfonamides / chemical synthesis
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Sulfonamides / chemistry*
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Sulfonamides / pharmacology
Substances
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Anti-Obesity Agents
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Receptors, Ghrelin
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Sulfonamides